Trials
Search / Trial NCT06423807

Preoperative Ondansetron Lozenge for Prevention of Post-Spinal Shivering in Caesarean Section

Launched by TANTA UNIVERSITY · May 16, 2024

Apply for Trial

Trial Information

Current as of March 13, 2025

Completed

Keywords

ClinConnect Summary

Spinal anesthesia (SA) is preferred for cesarean section (CS) compared with general anesthesia(GA) because of several advantages, including prevention of the potential risk of GA-related neurotoxicity.

Post-spinal shivering (PSS) could be a provocative factor for postoperative pain and its appropriate treatment prevents non-thermoregulatory tremors. Shivering also causes aggravating postoperative pain by stretching of sutures.

Ondansetron is a selective antagonist for receptor 5-hydroxytryptamine 3 and is very effective in the prevention and treatment of shivering intra- and post-operatio...

Gender

FEMALE

Eligibility criteria

  • Inclusion Criteria:
  • • Age from 18 to 40 years.
  • • American Society of Anesthesiology (ASA) physical status II.
  • • Parturient women undergoing CS under spinal anesthesia.
  • Exclusion Criteria:
  • • Parturient women with any contraindication or hypersensitivity to the study drugs.
  • • Any history of cardiovascular diseases, psychosis, hypertension, fetal distress, cord prolapse initial.
  • • Temperature more than 38°C or less than 36°C.
  • • Body Mass Index (BMI)\> 40 kg/m2.
  • • Medical history of alcohol or drug abuse.
  • • Parkinson's disease or any extrapyramidal disease.
  • • Intraoperative blood transfusion.
  • • History of chemotherapy treatment.

Trial Officials

Mohammed S Elsharkawy, MD

Principal Investigator

Faculty of Medicine Tanta University, Egypt

About Tanta University

Tanta University is a prestigious academic institution located in Egypt, dedicated to advancing medical research and education. As a clinical trial sponsor, Tanta University leverages its extensive resources and expertise to conduct innovative research initiatives aimed at improving health outcomes. The university collaborates with a network of healthcare professionals, researchers, and institutions to facilitate rigorous clinical trials across various medical disciplines. Committed to ethical standards and scientific integrity, Tanta University strives to contribute to the global body of knowledge while fostering the next generation of medical professionals.

Locations

Tanta, El Gharbia, Egypt

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0