Thermogenic Silencer Regulatory Factors in Humans

Launched by ROCKEFELLER UNIVERSITY · May 15, 2024

Keywords

ClinConnect Summary

This clinical trial, titled "Thermogenic Silencer Regulatory Factors in Humans," is exploring a new way to help people with obesity and metabolic diseases by looking at a special type of fat in our bodies called brown fat. This brown fat can help burn calories and improve metabolism, but it often doesn’t work well at normal body temperatures. The researchers aim to find out why this happens so they can develop better treatments for obesity and related health issues.

To participate in the study, you should be between 18 and 35 years old, either lean (with a body mass index or BMI between 18.5 and 24.9) or obese (with a BMI over 30). If you have Type II diabetes, you can also join if you meet certain health criteria. Participants will undergo assessments related to their metabolism and body fat function. It's important to note that some people, like those with certain health conditions or medications, may not be eligible for this trial. If you qualify and choose to participate, you’ll be contributing to important research that could lead to new treatments for obesity and metabolic disorders.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age between 18 years old and 35
• • 2. Lean group: BMI is between 18.5 and 24.9. HgA1c \<5.7%
• • 3. Obese group: BMI is \>30, HgA1c \<5.7%
• • 4. Obese group with Type II diabetes: BMI is \>30, HgA1c is \>6.5% If on oral medication for diabetes management, HgA1c may be \< 6.5% The following medications are also acceptable: statins, aspirin, angiotensin-converting enzyme inhibitors (ACEi), and angiotensin receptor blockers (ARB).
• Exclusion Criteria:
• • 1. Diabetes type I (self-report)
• • 2. Diagnosis of thyroid disease (including goiter, hyperthyroidism, hypothyroidism, thyroiditis)(self-report)
• • 3. Diagnosis with cancer including skin cancer (self-report)
• • 4. Diagnosis or evidence of Raynaud's Syndrome or systemic sclerosis (self-report)
• • 5. A recent diagnosis of Coronavirus Disease 2019 (COVID-19) (last 2 weeks) or hospitalized at the time of diagnosis with COVID-19
• • 6. Any vaccine administration within two weeks preceding the study procedure
• • 7. Currently pregnant
• • 8. Currently taking any prescribed medication other than oral contraceptives. Treatments for weight loss or any other supplements that may alter weight or metabolism are not acceptable. Vitamins are acceptable.
• • 9. Has consumed nicotine (smoking, inhaling, ingesting) within the last 6 months
• • 10. Has used illicit drugs within the last 6 months (marijuana users are eligible unless consumed in the last 30 days).
• • 11. Any medical, psychological, or social condition that, in opinion of principle investigators, would jeopardize the health or well-being of the participant during the study procedure or the integrity of the data
• • 12. Diabetes Type II that is managed by insulin.
• • 13. Steroid use in the last 30 days to the exclusions