Effects of an Antioxidant Supplement on Blood Vessel Health

Launched by UNIVERSITY OF GEORGIA · May 16, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the effects of an antioxidant supplement on blood vessel health in healthy adults, particularly focusing on the non-Hispanic Black population. Researchers believe that oxidative stress, which is an imbalance between free radicals and antioxidants in the body, may be affecting blood vessel function and potentially leading to heart disease. The goal of this study is to see if the mitochondria, which are the energy-producing parts of our cells, play a role in this issue.

To join the study, participants should be between 18 and 75 years old, identify as either non-Hispanic Black or non-Hispanic White, and have healthy blood pressure and cholesterol levels. They should not have any significant skin conditions, smoking habits, or certain medical issues like diabetes or heart disease. Those who qualify will be asked to take the antioxidant supplement and will be monitored to see how it affects their blood vessel health. This trial aims to gather important information that could help improve cardiovascular health in communities that are more affected by heart disease.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Self-identify as either non-Hispanic Black or non-Hispanic White.
• • Men and women 18-75 years old.
• • Non-hypertensive (systolic blood pressure \[SBP\]\<130 and diastolic blood pressure \[DBP\] \<85 mmHg).
• • Have low density lipoprotein cholesterol \<150mg/dl.
• • Have HbA1C \<6.0%.
• Exclusion Criteria:
• • Rash, skin disease, or disorders of pigmentation (e.g., psoriasis, eczema, vitiligo, or other skin inflammatory skin disorders)
• • Known skin allergies to latex or adhesives
• • Smoking and/or use of nicotine-containing products within the past year
• • Use of illegal/recreational drugs
• • Generalized kidney disease
• • Taking chloramphenicol, cholestyramine, medication for seizures, methotrexate, nitrofurantoin, tetracycline, barbiturates, steroids, phenobarbital/phenytoin, orlistat or pyrimethamine
• • Any current medications which could conceivably alter the cardiovascular control or responses
• • Diagnosed or suspected metabolic or cardiovascular disease
• • Current pregnancy or breastfeeding
• • History of skin or other cancers
• • Diagnosed or suspected diabetes (HbA1c ≥6.0)
• • Anybody with narcolepsy or who has been diagnosed with any condition that impairs body temperature regulation.