Vonafexor ALPort Syndrome Efficacy & Safety TRIAl-1 (ALPESTRIA-1)

Launched by ENYO PHARMA · May 17, 2024

Keywords

ClinConnect Summary

The ALPESTRIA-1 trial is studying a new medication called vonafexor to see how safe it is and how it might help people with Alport syndrome, which is a condition that affects the kidneys and can lead to serious health issues. This trial is currently looking for participants who are between 58 and 200 years old and have a confirmed diagnosis of Alport syndrome. To qualify, they should have certain levels of kidney function and protein in their urine, and they need to be on stable treatments for any other health conditions before joining the study.

If you or someone you know is interested in participating, you can expect to undergo some assessments and follow study guidelines to ensure safety throughout the trial. It's important to note that certain health conditions or medications may prevent eligibility, so potential participants will have a thorough screening process. This study aims to gather important information that could help improve the care and treatment options for individuals with Alport syndrome.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Signed informed consent (also for legal representatives, as applicable in the US for under eighteen patients).
• • Has confirmed diagnosis of Alport syndrome: clinical diagnosis (haematuria, family history, hearing loss, ocular change) OR a kidney biopsy showing glomerular basement membrane abnormalities consistent with AS, AND Genetic confirmation of AS.
• • Has eGFR between ≥ 30 and \< 90 ml/min/1.73m2.
• • Has increased albuminuria criteria i.e. UACR ≥ 300 mg/g.
• • If on an angiotensin converting enzyme inhibitor (ACEi) and/or angiotensin receptor blocker (ARB), should be on a stable well tolerated treatment during at least the 60 days prior D1.
• • If on Sodium-Glucose Transport Protein 2 (SGLT2), should be on stable well tolerated treatment with SGLT2 during at least 60 days prior D1.
• • If patient has a history of arterial hypertension, should be on stable anti-hypertensive therapy for at least 60 days prior to D1 and deemed controlled by the investigator at screening and D1.
• • Sexually active female subjects of childbearing potential and sexually mature male subjects must use two acceptable effective methods of contraception for the entire duration of the study and for at least 6 weeks after last dose.
• • Has negative results for hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV) antibody, and human immunodeficiency virus (HIV).
• • Is able to understand all study procedures in the informed consent form (ICF) and willing to comply with all aspects of the protocol.
• Exclusion Criteria:
• • Is an employee of a site, clinical research organization, vendor, or sponsor involved with this study.
• • Is pregnant or breastfeeding.
• • Has participated in any investigational drug study within 60 days prior to D1.
• • Any clinically significant illness within 30 days before D1 or surgical or medical condition (other than Alport syndrome) that could interfere with the subject's study compliance; confound the study results; impact subject safety.
• • Any history of active malignancy within the last 1 year before D1.
• • Any other condition or circumstance that, in the opinion of the investigator, may make the subject unlikely to complete the study or comply with study procedures and requirements, or may pose a risk to the subject's safety and well-being.
• • Has a history of an allergic condition that required the prescription of an emergency epinephrine injection (such as the EpiPen® Auto-Injector).
• • Any prohibited co-medications within 30 days prior D1.
• • Has ALT or AST above near normal (\>1.5×ULN) at baseline.
• • Are at high risk for atherosclerotic cardiovascular disease (ASCVD) risk, with an LDL-C level \> 160 mg/dL (4.15 mmol/L) and subjects at intermediate risk for ASCVD risk, with a LDL-C level \> 190 mg/dL (4.91 mmol/L).
• • Has moderate or severe hepatic impairment (Child-Pugh score B or C).
• • Is taking CYP3A4/5 inhibitors or inducers.