Point-of-Care Lung Ultrasound for Prognosis in Critically Ill Infants With Acute Lower Respiratory Tract Infection

Launched by VITTORE BUZZI CHILDREN'S HOSPITAL · May 16, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how using a special type of ultrasound, called Point-of-Care Ultrasound (POCUS), can help doctors predict how well critically ill infants with breathing problems, like bronchiolitis, will respond to noninvasive treatments in the Intensive Care Unit (ICU). Researchers want to find out if certain ultrasound findings in the lungs can indicate whether a baby's condition will improve or if they will need more intensive support, like a breathing machine. The trial will compare ultrasound results taken within the first day of ICU care to results from the following day.

To participate in this study, infants must be less than one year old and admitted to the Pediatric Intensive Care Unit (PICU) for suspected or confirmed lower respiratory infections. They should be receiving noninvasive breathing support within the first 12 hours of their ICU stay. However, infants who are already on invasive ventilation or have other specific health issues will not be eligible. Parents can expect that their child will undergo the ultrasound as part of their routine care in the ICU, and this may help doctors make better decisions about their treatment.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age \<1 year at the time of hospital admission
• • 2. Admission to PICU for suspected/confirmed LRTI
• • 3. Treatment (within the 1st 12 hours of ICU stay) with noninvasive ICU-LRS for respiratory failure (HFNC \>1L/kg/min, negative pressure, or noninvasive PPV via any interface (CPAP, BiPap, NIMV, etc.)
• Exclusion Criteria:
• • 1. Invasive ventilation as initial support or within the 1st 12 hours of ICU stay, either via endotracheal tube or tracheostomy
• • 2. Upper respiratory symptoms only (stridor, stertor)
• • 3. Corrected gestational age \<37 weeks at time of ICU admission
• • 4. ICU-LRS for only nonrespiratory reasons (e.g. shock) or for pulmonary edema felt to be solely due to noninfectious causes (cardiogenic, airway obstruction, drowning). Patients presenting with apnea can be included if they have a diagnosis of bronchiolitis or other LRTI
• • 5. Prior inclusion in the study