Tobacco, Alcohol and Cancerization of the Oral Mucosa (TACO)

Launched by CENTRE LEON BERARD · May 17, 2024

Keywords

ClinConnect Summary

The TACO clinical trial is focused on studying changes in the healthy tissue of the mouth in patients who have been diagnosed with oral squamous cell carcinoma, a type of cancer that affects the mouth. By examining the DNA of the normal mouth tissue, researchers hope to learn more about how tobacco and alcohol might play a role in the development of this cancer. This research could help improve understanding of the disease and potentially lead to better prevention strategies.

To participate in the trial, you need to be at least 18 years old and have a confirmed diagnosis of oral squamous cell carcinoma. You should not have received any prior treatment for cancer, such as chemotherapy or radiation. The study is open to both men and women, and you will need to be covered by medical insurance. If you join the trial, you can expect to undergo some tests to collect samples of your healthy oral tissue, which will help researchers gather important information. It's also important to know that certain health conditions or treatments may exclude you from participating, so discussing your situation with a healthcare provider is essential.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • I1. Male or female aged 18 years or older at the date of signature of the informed consent to participate.
• • I2. Patient with histological diagnosis of epidermoid carcinomas of the oral cavity NB: All grades are eligible.
• • I3. Patient naive of any systemic anti-cancer treatment (radio- or chemotherapy).
• • I4. Patient able to understand, sign and date informed consent before the start of any study protocol procedure.
• • I5. Patient affiliated or covered by a medical insurance
• Exclusion Criteria:
• • E1. Patients at high risk of bleeding, such as those on anticoagulant or antiplatelet aggregant treatment, with clotting disorders or a history of severe bleeding in the two weeks prior to inclusion.
• • E2. Patient with lesions of all types on the mucosa of the cheek located on the opposite side of the area affected by an epidermoid carcinoma of the oral cavity which prevents painless removal of the healthy mucosa.
• • E3. Patient who had surgery for their epidermoid carcinoma of the oral cavity more than 6 months ago.
• • E4. Patient who uses cannabis.
• • E5. Patient with another active tumor or HPV-positive tumors.
• • E6. Patient under guardianship or curatorship or placed under the protection of justice.
• • E7. Pregnant and/or nursing patient.

Trial Officials