Microfragmented Adipose Tissue Injection Compared to Hyaluronic Acid for Treatment of Temporomandibular Joint Osteoarthritis

Launched by CAIRO UNIVERSITY · May 17, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating a new treatment for people with osteoarthritis of the temporomandibular joint (TMJ), which is the joint that connects your jaw to your skull. The study will compare two treatments: one using microfragmented adipose tissue (a type of fat taken from the patient’s own body) and the other using hyaluronic acid (a substance often used to treat joint pain). Researchers believe that using microfragmented adipose tissue may be a better way to preserve important stem cells that can help heal the joint.

To be eligible for this trial, participants need to be 14 years or older and have been diagnosed with TMJ osteoarthritis, which is confirmed through clinical exams and MRI scans. They should experience symptoms like limited mouth opening and joint pain, and must not have had any previous TMJ surgeries. Additionally, they should have tried other treatments without success. The trial is not yet recruiting participants, but it aims to gather important information about these treatments to help improve care for people with TMJ issues. Participants will receive careful monitoring and support throughout the study to ensure their safety and well-being.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • \* TMJ osteoarthritis assessed by clinical examination and MRI imaging
• • Presence of TMJ-related symptoms including at least limited mouth opening and joint pain
• • Previously failed conservative treatment
• • Age superior to 14 years
• • No previous TMJ surgical procedures
• • Acquisition of informed consent;
• • Complete availability of the data acquired preoperatively and during each follow-up
• • Patients free from any systemic disease that may affect the procedure.
• Exclusion Criteria:
• • \* Previously diagnosed hematological and neurological conditions;
• • Previous malignant head and neck neoplasms;
• • Contraindication to fat harvesting.
• • Uncooperative patients.