Macrohemodynamic Impact of Fluid Removal With Net Ultrafiltration in Patients With Continuous Renal Replacement Therapy

Launched by HOSPICES CIVILS DE LYON · May 21, 2024

Keywords

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Gender

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Eligibility criteria

• Inclusion Criteria:
• • Acute kidney injury treated by continuous renal replacement therapy in ICU less than 7 days,
• • At least 1 organ failure during ICU in addition to AKI (mechanical ventilation or vasopressors administration\>12 hours),
• • Cumulative UF net less than 1000ml before inclusion,
• • Norepinephrine \< 0,5 µg/kg/min,
• • Absence of hypoperfusion signs,
• • Fluid overload defined as follows: fluid overload \> 5% of base weight (based on cumulative fluid balance or a weight gain) and/or peripheral edema (AKIKI edema scale \> 2).
• Exclusion Criteria:
• • Chronic renal failure hemodialyzed before admission to the ICU,
• • Mechanical circulatory support (ECMO, LVAD),
• • Pregnant, child -bearing age or lactating women,
• • Stroke less than 30 days,
• • Intestinal ischemia less than 7 days documented non-operated,
• • Interventional study participation or exclusion period on going,
• • Guardianship, curatorship or safeguard of justice,
• • Absence of signature of free and informed consent by the patient and/or relative,
• • Patients not affiliated to a social security scheme or beneficiaries of a similar scheme
• • Absence of transpulmonary thermodilution monitoring