Macrohemodynamic Impact of Fluid Removal With Net Ultrafiltration in Patients With Continuous Renal Replacement Therapy

Launched by HOSPICES CIVILS DE LYON · May 21, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how removing excess fluid from critically ill patients who are receiving a special type of dialysis called continuous renal replacement therapy (CRRT) affects their overall blood circulation. The goal is to see if a method called net ultrafiltration can help improve patients' health by safely reducing fluid overload, which can be a serious issue for patients in intensive care. The trial is part of a larger study and is not yet recruiting participants.

To be eligible for this trial, patients must be aged between 65 and 74 and have acute kidney injury that is being treated with CRRT in the ICU for less than a week. They should also have at least one other organ failure and show signs of fluid overload, which means they have gained more than 5% of their body weight due to fluid retention. Participants will be closely monitored throughout the study, and their safety and well-being will be a top priority. This trial aims to find better ways to manage fluid levels in critically ill patients, potentially leading to improved care in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Acute kidney injury treated by continuous renal replacement therapy in ICU less than 7 days,
• • At least 1 organ failure during ICU in addition to AKI (mechanical ventilation or vasopressors administration\>12 hours),
• • Cumulative UF net less than 1000ml before inclusion,
• • Norepinephrine \< 0,5 µg/kg/min,
• • Absence of hypoperfusion signs,
• • Fluid overload defined as follows: fluid overload \> 5% of base weight (based on cumulative fluid balance or a weight gain) and/or peripheral edema (AKIKI edema scale \> 2).
• Exclusion Criteria:
• • Chronic renal failure hemodialyzed before admission to the ICU,
• • Mechanical circulatory support (ECMO, LVAD),
• • Pregnant, child -bearing age or lactating women,
• • Stroke less than 30 days,
• • Intestinal ischemia less than 7 days documented non-operated,
• • Interventional study participation or exclusion period on going,
• • Guardianship, curatorship or safeguard of justice,
• • Absence of signature of free and informed consent by the patient and/or relative,
• • Patients not affiliated to a social security scheme or beneficiaries of a similar scheme
• • Absence of transpulmonary thermodilution monitoring