Characterization of Left Atrial Substrate in Patients With Ventricular Arrhythmias

Launched by UNIVERSITAIR ZIEKENHUIS BRUSSEL · May 21, 2024

Keywords

ClinConnect Summary

This clinical trial is looking into the heart's left atrium, specifically to understand how its structure might change in patients who are at high risk for developing a heart rhythm problem called atrial fibrillation. The researchers want to find out if these changes are early signs of atrial fibrillation or if they happen because of it. They will compare the heart maps of patients who have not yet experienced atrial fibrillation but have some heart disease, to those who have already been diagnosed with this condition.

To be eligible for the study, participants must not have a history of atrial fibrillation or flutter and should have a certain level of heart disease, indicated by a scoring system called CHA2DS2-VASc, which assesses the risk of stroke. During the study, participants can expect to undergo tests that create detailed maps of the left atrium's electrical activity. This trial is currently recruiting people aged 65 and older, regardless of gender. Understanding these heart changes may help doctors predict and prevent future heart issues for patients at risk.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Absence of a prior history of atrial fibrillation or flutter.
• • Patients presenting for ablation of any ventricular tachycardia related to structural heart disease or any ventricular arrhythmia with a CHA2DS2-VASc score ≥ 2.
• Exclusion criteria:
• • Presence of thrombus in the left atrial appendage.
• • Complications related to the index procedure.
• • Insufficient quality of the left atrial electroanatomical map.

Trial Officials