Ketosis Impact on Signs & Symptoms of Schizophrenia and Bipolar disorderS

Launched by ACADEMISCH MEDISCH CENTRUM - UNIVERSITEIT VAN AMSTERDAM (AMC-UVA) · May 17, 2024

Keywords

ClinConnect Summary

This clinical trial is studying whether a special drink made from ketones can help improve symptoms in individuals with schizophrenia or bipolar disorder. The main goal is to find out if this drink can enhance how well patients process information and think clearly. Researchers will compare the effects of the ketone drink to a similar drink made from carbohydrates, allowing them to see which one works better for the participants.

To be eligible for this trial, participants need to be at least 18 years old and experiencing their first episode of psychosis related to schizophrenia or a (hypo)manic or depressive episode related to bipolar disorder. It’s important that they are receiving standard medical care, including medications for their condition. During the study, participants will drink both types of beverages and undergo various tests to measure their thinking abilities, mood, and overall health over several days. They will also wear devices to monitor their glucose levels and gather information about their diet and energy use. This trial is currently recruiting, and it aims to provide valuable insights into new ways to support individuals with these mental health conditions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with a first-episode psychosis (underlying schizophrenia-spectrum disorder), or patients with a (hypo)manic or depressive episode (underlying bipolar disorder)
• • Age \>= 18 years old
• • Receiving standard care (including antipsychotic and mood stabilizing medication)
• * Mentally competent to give informed consent:
• Exclusion Criteria:
• • Substance use as cause of psychosis or (hypo)mania
• • Substance use (other than nicotine) in the week prior to study onset
• • Intellectual disability
• • Diabetes mellitus (type 1 or type 2)
• • Metabolic disease impacting ketone metabolism (NB: these are rare disorders diagnosed during childhood)
• • Liver disease
• • Kidney disease
• • Cardiovascular disease
• • Pregnancy
• • Breastfeeding