The Role of Cytokines and Regulatory T Lymphocytes in Migraine Pathophysiology.

Launched by UNIVERSITY HOSPITAL, CLERMONT-FERRAND · May 22, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating the role of specific immune system cells and chemicals (called cytokines) in understanding migraines, a painful condition that affects many people, especially women. Researchers want to learn more about how these immune factors might be involved in migraines, particularly in individuals who also have autoimmune or inflammatory diseases like multiple sclerosis or rheumatoid arthritis. They will compare levels of certain immune cells and cytokines in women who experience migraines with those who do not, while also considering their health history.

To participate in the study, women aged 18 to 50 who weigh at least 50 kg and do not have certain conditions, such as menopause or active cancer, may be eligible. Participants will need to avoid having a migraine attack close to the blood tests. The trial is not yet recruiting, but when it begins, participants will help researchers gain valuable insights that could lead to better treatments for migraines. This is an important step toward understanding why some people suffer from migraines and how to improve their care.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • female
• • 18 - 50 years of age
• • at least 50 kg
• • autoimmune/inflammatory disease groups : with a diagnosis of multiple sclerosis, systemic lupus erythematous, rheumatoid arthritis, Crohn's disease, type 1 diabetes or endometriosis
• • migraine group : with a diagnosis of migraine with at least 4 headache days per month
• Exclusion Criteria:
• • BMI \< or = 17 ou \> or = 30kg/m²
• • type 2 diabetes, immune deficit, other chronic autoimmune or inflammatory disease
• • non-migraine headache, except for tension type headache of less than 4 days/month
• • pregnancy, delivery, miscarriage, breast-feeding, participation in a medically assisted human reproduction program (ovary stimulation/hormone therapy) \< 3 months before blood sampling
• • Menopause, hysterectomy, or bilateral oophorectomy
• • Hormone therapy (besides contraception and treatment of endometriosis)
• • bone marrow or solid organ transplant
• • guardianship, curatorship, safeguard of justice or deprivation of liberty
• • for patients : diagnosis of several autoimmune or inflammatory diseases
• • for controls : diagnosis of an autoimmune or inflammatory disease
• • for non-migraine participants : migraine