Predictive Effect of TGF-β and INS-PI3K-AKT Related Proteins for POD in Diabetes Patients

Launched by XIE KANGJIE · May 19, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how certain proteins in the body might help predict the risk of postoperative delirium (POD) in older adults with diabetes. Postoperative delirium is a temporary confusion that can occur after surgery, especially in people with diabetes. The researchers want to understand how proteins related to the TGF-β and INS-PI3K-AKT signaling pathways might be connected to this condition. The goal is to find ways to better predict who might be at risk, so doctors can provide better care.

To participate in this study, you need to be at least 65 years old and have been diagnosed with diabetes for at least two years, or have normal blood sugar levels. You should also be scheduled for certain types of surgery on your chest or abdomen. Participants will undergo tests to evaluate their cognitive function and may have blood samples taken to study the proteins in question. If you have certain health conditions or are taking specific medications, you may not be eligible to join. Overall, the study aims to improve understanding of how diabetes affects recovery after surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≥65 years
• • 2. History of diabetes ≥2 years and Glycated hemoglobin ≥6.5% or no history of diabetes and normal blood glucose
• • 3. The ASA rating is Class I to III
• • 4. The elderly patients of limited thoracic and abdominal tumor surgery
• Exclusion Criteria:
• • 1. Refused to participate
• • 2. Previous history of schizophrenia, epilepsy, Parkinson's disease
• • 3. History of alcohol abuse or drug dependence
• • 4. Patients with ASA grade IV and above
• • 5. Severe visual or hearing impairment, can not cooperate with the completion of cognitive function tests
• • 6. Participants in other clinical trials within the last two months
• • 7. Patients with severe arrhythmia or cardiac dysfunction(EF\<40%)
• • 8. There was a clear history of neurological and psychiatric problems or long-term use of sedatives or antidepressants
• • 9. History of cerebrovascular disease or brain surgery or trauma
• • 10. Severe liver dysfunction (Child-Pugh class C) or severe renal dysfunction (requiring dialysis)

Trial Officials