Routinely Collected Clinical Data and Evaluation of Antimicrobial Target Attainment

Launched by IMPERIAL COLLEGE LONDON · May 21, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how well patients at Imperial College Healthcare NHS Trust are able to achieve the right levels of beta-lactam antibiotics in their bodies. These antibiotics are commonly used to treat bacterial infections. The main goal is to find out how many patients receiving these medications are reaching the target drug concentrations needed for them to be effective.

To participate in the trial, you need to be at least 18 years old and currently being treated for an infection at the hospital. You must have received a beta-lactam antibiotic in the last 48 hours or be scheduled to start one soon. If you join the study, you’ll be asked to give your consent, or if you’re unable to do so due to your medical condition, a family member or legal representative can help. The trial is currently recruiting participants, and it’s important to know that those with severe blood disorders or who are receiving end-of-life care cannot participate. If you choose to take part, you will be contributing to valuable research that could help improve treatment for others in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 18 years of age or above.
• • Under follow-up for management of infection at Imperial College NHS Trust
• • Received a beta-lactam antibiotic within the last 48 hours (or are planned to start imminently).
• * Provides informed written consent see below, or lacks capacity to provide consent because of one of the following conditions (and declaration provided by personal consultee):
• • Delirium which may be caused or exacerbated by having an infection.
• • Suspected/confirmed central nervous system infection.
• • Critical illness requiring sedation and/or intubation and ventilation which is caused by or exacerbated by having an infection.
• Exclusion Criteria:
• • Less than 18 years of age
• • Severe anaemia (Hb \< 70g/l)
• • Platelets \< 50x10\^9/l, INR \>1.5 or other known blood clotting impairment
• • Patient with terminal diagnosis receiving palliative care input who may experience distress if approached for this study.
• • Enrolled in a clinical trial which stipulates exclusion from other studies including observational studies.
• • Patients with restricted liberty, prisoners or under legal protection.