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Search / Trial NCT06427512

Mechanisms Underlying Cardiovascular Consequences Associated With COVID-19 and Long COVID

Launched by COLUMBIA UNIVERSITY · May 20, 2024

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Trial Information

Current as of March 14, 2025

Withdrawn

Keywords

Long Covid 19

ClinConnect Summary

As many as 40-60% of patients who recovered from mild or moderate acute COVID have reported what is now called long COVID - multiple, persistent or recurrent symptoms lasting 6-9 months (or longer) following initial illness.1-4 Fatigue, dyspnea, and chest pain are the most common symptoms. Others include palpitations, lightheadedness, and syncope. All these cardiovascular symptoms can be debilitating, resulting in worse quality of life and morbidity.5, 6 Treatment options are limited.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • • Age \> 18, \< 75 yrs
  • • History of lab-confirmed COVID
  • • Symptomatic at \>12 wks post-acute COVID (cases)
  • • Recovered by 8wks post-acute COVID (controls)
  • Exclusion Criteria:
  • • Any history of critical illness
  • • Chronic kidney disease, Stage \>4
  • • Pre-COVID: HFrEF, CABG, arrhythmia; pulmonary hypertension, pulmonary embolus, interstitial lung disease (ILD), O2 dependence; dementia, stroke, autonomic dysfunction; coagulopathy
  • • Post-COVID: ILD, O2 dependence

Trial Officials

Emily Tsai, MD

Principal Investigator

Florence Irving Associate Professor of Medicine, Dept of Medicine Cardiology

About Columbia University

Columbia University, a prestigious Ivy League institution located in New York City, is a leading sponsor of clinical trials dedicated to advancing medical research and improving patient care. With a robust network of research facilities and a commitment to innovation, Columbia University collaborates with a diverse range of healthcare professionals and researchers to explore groundbreaking therapies and treatment methodologies. The university's clinical trials encompass various fields, including oncology, neurology, and public health, aiming to translate scientific discoveries into effective clinical applications. Columbia University is dedicated to maintaining the highest ethical standards and regulatory compliance, ensuring the safety and well-being of trial participants while contributing to the global body of medical knowledge.

Locations

New York, New York, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0