Comparative Efficacy of Dexamethasone - Ondansetron Versus Dexamethasone - Haloperidol in Reducing PONV

Launched by UNIVERSITAS PADJADJARAN · May 20, 2024

Keywords

ClinConnect Summary

Postoperative nausea and vomiting (PONV) are also known as the little problem interpreted as a seemingly less significant complication but lead to increased morbidity, longer hospital stays, increased medical costs, and diminished patient satisfaction with healthcare services. These symptoms are reported more frequently than postoperative pain, making its prevention as important as postoperative pain management. In laparoscopic cholecystectomy, the occurrence of PONV can range from 40 - 70%, which is higher than the 33 - 49% observed in other types of surgeries under general anesthesia with...

Gender

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Eligibility criteria

• Inclusion Criteria:
• • Patients undergoing laparoscopic cholecystectomy
• • aged 18 - 65 years
• • ASA physical status 1 and 2
• • Apfel score ≥2
• Exclusion Criteria:
• • a history of allergies
• • routine use of antipsychotic drugs, steroids, antihistamines, and antiemetics before surgery
• • cardiac rhythm disorders
• • elevated liver enzyme levels (SGOT/SGPT) ≥5 times upper limit normal
• • BMI ≥35 kg/m2
• Dropout Criteria:
• • if they experienced hypotension, defined as systolic blood pressure below 90 mmHg or mean arterial pressure (MAP) below 60 mmHg, or a decrease in systolic blood pressure and/or MAP greater than 20% from baseline for a duration exceeding two minutes, surgical procedures extending \>3 hours, and any alterations in the planned surgical intervention.

Trial Officials