The Preventive Role of Fractionated Laser Resurfacing Against Actinic Neoplasia in an At-Risk Geriatric Population

Launched by WRIGHT STATE UNIVERSITY · May 20, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the effects of a procedure called Fractionated Laser Resurfacing (FLR) to see if it can help protect older adults from developing precancerous skin conditions known as actinic keratoses (AKs) and potentially prevent skin cancer. The focus is on individuals aged 60 and older who have at least five AKs on each of their forearms or wrists. The study will also explore whether taking photographs of the skin can help predict where these precancerous spots might appear in the future.

To participate, you need to be 60 years or older, have between five and ten AKs on your forearms or wrists (so they can be monitored easily), and have fair skin (skin types I or II). Participants should be able to understand the study's procedures and risks. This trial is currently recruiting volunteers, and if you join, you can expect to be monitored closely throughout the study. It’s important to know that there are some health conditions and recent treatments that could prevent you from being eligible, so discussing your health history with the study team is essential.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult Males and Females aged 60 and older
• • Have at least 5 AKs on each forearm/wrist, but no more than 10 to allow for easy monitoring
• • Skin type fair (Fitzpatrick I-II)
• • Females must be post-menopausal and not be on systemic hormone replacement therapy
• • Able to comprehend procedures and risks
• Exclusion Criteria:
• • More than 10 AKs on an extremity
• • AKs that are large (2-3+, hyperkeratotic grade 3 lesions)
• • AKs that are very thick (\>3 mm)
• • Medical history of diabetes
• • History of poor wound healing or scarring
• • Large tattoos that can interfere with study
• • Other serious health issues and other skin diseases that could interfere with the study
• • Recent (within 1 year) field therapies such as efudex cream or PDT to forearms/wrists.
• • Planning to leave region in next 5 years
• • Subjects with allergies to xylocaine will be excluded if they need this topical anesthetic.