International Care Bundle Evaluation in Cerebral Hemorrhage Research

Launched by REGION SKANE · May 20, 2024

Keywords

ClinConnect Summary

The I-CATCHER trial is studying a new treatment approach for patients who experience spontaneous intracerebral hemorrhage (ICH), which is a type of stroke caused by bleeding in the brain. This trial will compare a structured treatment package, known as a Care Bundle, to the standard care typically provided. The goal is to see if this new treatment can lead to better health outcomes for patients within three months of their stroke. The Care Bundle includes early measures like lowering blood pressure and managing fever and high blood sugar, which have shown promise in previous studies.

To participate in the trial, individuals must be adults aged 18 or older and have been diagnosed with spontaneous ICH within 24 hours of their symptoms starting. However, certain people may not be eligible, such as those with specific severe health conditions or certain types of brain bleeding. While the trial is not yet recruiting participants, those who take part can expect to receive either the new treatment package or the usual care, and their progress will be closely monitored to assess the effectiveness of the new approach. This study is important as it aims to improve treatment for ICH patients in Sweden, Australia, and other high-income countries.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults (age ≥18 years)
• • Non-contrast computerized tomography (NCCT) imaging-verified diagnosis of spontaneous intracerebral haemorrhage
• • ≤24 hours from symptom onset or presumed symptom onset (last seen well)
• Exclusion Criteria:
• • Previous care limitation
• • End-stage comorbidity with short life-expectancy (\<6 m; e.g. terminal cancer)
• • ICH caused by brain tumor or cerebral venous thrombosis
• • Clinical signs of brain herniation at first presentation (unresponsive patient with bilaterally fixed, maximally dilated pupils)
• • Pregnant women beyond 22 weeks gestation may only be included after thorough discussion with an obstetrician to determine risks vs benefit.