Metabolomic Profile of Vitreoretinal Diseases: an NMR-Based Approach Using Vitreous.

Launched by RENMIN HOSPITAL OF WUHAN UNIVERSITY · May 21, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the chemical markers, or metabolomic profiles, found in the vitreous fluid (the jelly-like substance in the eye) of patients with specific eye diseases. The research focuses on common conditions such as idiopathic macular hole (IMH), diabetic retinopathy (DR), and retinal detachment (RD). By examining these fluid samples, the goal is to identify any unusual biomarkers that could help us better understand these diseases. Importantly, participants will not receive any treatments or interventions; instead, the study will only collect information and samples before their scheduled eye surgery.

To be eligible for the trial, participants must have a confirmed diagnosis of one of the targeted eye diseases and need to undergo a specific type of surgery called pars plana vitrectomy (PPV). Those who don’t need surgery, have had previous similar surgeries, or have other serious eye or health conditions may not qualify. If you choose to participate, you'll help contribute to valuable research that could improve the understanding and treatment of these eye conditions in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Confirmation of IMH diagnosis with concomitant need for PPV surgery;
• • 2. Confirmation of DR diagnosis with concomitant need for PPV surgery;
• • 3. Confirmation of RD diagnosis with concomitant need for PPV surgery;
• • 4. Confirmation of IMM diagnosis with concomitant need for PPV surgery;
• • 5. Confirmation of RVO diagnosis with concomitant need for PPV surgery.
• Exclusion Criteria:
• • 1. Diagnosed vitreoretinal disease with no need for PPV surgery;
• • 2. Previous history of PPV surgery;
• • 3. Combination of other active ophthalmic diseases, such as acute conjunctivitis and uveitis;
• • 4. Combination of serious systemic diseases such as hypertension and diabetes mellitus.