The Clinical Investigation of Colgate Dual Zinc Toothpaste as Compared to Colgate Cavity Protection Toothpaste in Controlling Established Plaque and Gingivitis

Launched by COLGATE PALMOLIVE · May 24, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how well a new toothpaste called Colgate Dual Zinc Toothpaste works compared to Colgate Cavity Protection Toothpaste in controlling plaque and gingivitis (a common gum disease). The study will include participants aged 18 to 70 who have good general health and a specific level of plaque and gum issues. Those interested in participating must have at least 20 natural teeth and be available for the three-month duration of the study.

If you join the trial, you will be randomly assigned to use one of the two toothpastes for three months. After this period, you'll return to the dental office for a check-up to see how well the toothpaste worked for you. Throughout the study, your health will be monitored for any side effects. It's important to know that certain conditions, like having advanced gum disease or specific dental issues, may make you ineligible to participate. This study is not yet recruiting participants, so keep an eye out if you're interested!

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Subjects, ages 18-70, inclusive.
• • Availability for the three-month duration of the clinical research study.
• • Good general health.
• • Minimum of 20 uncrowned permanent natural teeth (excluding third molars).
• • Initial gingivitis index of at least 1.0 as determined by the use of the Loe and Silness Gingival Index.
• • Initial plaque index of at least 1.5 as determined by the use of the Quigley and Hein Plaque Index (Turesky Modification).
• • Signed Informed Consent Form
• Exclusion Criteria:
• • Presence of orthodontic bands.
• • Presence of partial removable dentures.
• • Tumor(s) of the soft or hard tissues of the oral cavity.
• • Advanced periodontal disease (purulent exudate, tooth mobility, and/or extensive loss of periodontal attachment or alveolar bone).
• • Five or more carious lesions requiring immediate restorative treatment.
• • Antibiotic use any time during the one month prior to entry into the study.
• • Participation in any other clinical study or test panel within the one month prior to entry into the study.
• • Dental prophylaxis during the past two weeks prior to baseline examinations.
• • History of allergies to oral care/personal care consumer products or their ingredients.
• • On any prescription medicines that might interfere with the study outcome.
• • An existing medical condition which prohibits eating or drinking for periods up to 4 hours.
• • History of alcohol or drug abuse.
• • Pregnant or lactating subjects