Effect of Infections and Global DNA Methylation on Frailty Trajectories in Hospitalized Older Patients (INFRAGEN)
Launched by UNIVERSITY HOSPITAL OF FERRARA · May 22, 2024
Trial Information
Current as of February 19, 2025
Not yet recruiting
Keywords
ClinConnect Summary
Infectious diseases are among the most common causes of hospitalization in older adults. Indeed, recent data report that more than 15% of hospital admissions in adults 65 years or older are due to infections, mainly in the urinary and respiratory tracts. Frailty is a well-known geriatric syndrome characterized by reduced individual resilience and increased vulnerability to external stressors. The prevalence of frailty ranges from around 10% in the community setting to almost 50% among institutionalized individuals.
Although both infectious diseases and frailty are associated with negative ...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • confirmed diagnosis of acute infection diseases at hospital admission or during the hospital stay, according to specific ICD-9 codes with or without systemic inflammatory reaction;
- • pre-admission non-frailty or mild frailty assessed using the Clinical Frailty Scale (CFS \< 6).
- Exclusion Criteria:
- • terminally ill patients with an estimated life expectancy less than 3 months;
- • presence of pre-admission frailty (CFS ≥ 6);
- • unwillingness to participate in the study or to complete the follow-up assessments
Trial Officials
Stefano Volpato, MD
Principal Investigator
Università degli Studi di Ferrara
About University Hospital Of Ferrara
The University Hospital of Ferrara, a leading academic medical institution in Italy, is dedicated to advancing healthcare through innovative research and clinical excellence. Affiliated with the University of Ferrara, the hospital is known for its commitment to integrating cutting-edge scientific inquiry with patient care. With a multidisciplinary approach, the institution conducts a wide range of clinical trials aimed at enhancing treatment methodologies and improving patient outcomes in various medical fields. The University Hospital of Ferrara prioritizes ethical standards and patient safety, fostering a collaborative environment that engages researchers, healthcare professionals, and patients in the pursuit of medical advancement.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
People applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Discussion 0