Liposomal Bupivacaine vs Ropivacaine for TAPBs

Launched by SUN YAT-SEN UNIVERSITY · May 21, 2024

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ClinConnect Summary

This clinical trial is studying two pain relief methods for patients undergoing laparoscopic surgery to remove lower abdominal tumors. The researchers want to compare the effectiveness of two medications: Liposomal Bupivacaine (LB) and Ropivacaine. Both are types of local anesthetics used during a specific procedure called a TAP block, which helps manage pain after surgery. The goal is to see which medication helps reduce the need for opioids (strong painkillers) after the operation.

To be eligible for this trial, participants need to be between 18 and 70 years old and should be scheduled for laparoscopic lower abdominal tumor surgery. Certain health conditions may exclude some patients, such as a history of opioid or local anesthetic allergies, severe heart issues, or other serious health problems. If you join the study, you can expect to receive one of the two medications during your procedure and will be monitored afterward for pain management and any side effects. This trial is currently recruiting participants, and it's a great opportunity to help improve pain management options for future patients.

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ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients undergoing laparoscopic resection of lower abdominal tumors
• • 2. ASA grade II-III
• • 3. Age: 18-70 years.
• Exclusion Criteria:
• • 1. (1) The patient does not agree to participate in the clinical study
• • 2. (2) The patient has a clear history of opioid tolerance or allergy
• • 3. (3) The patient has a history of local anesthetic allergy
• • 4. (4) Previous history of dementia, mental illness or other central nervous system diseases
• • 5. (5) Have a history of chronic pain or are taking opioids and other analgesics
• • 6. (6) Patients are generally in poor condition with a history of serious diseases of cardiovascular system, respiratory system, digestive system, urinary system or central nervous system, and may not survive for more than 3 months
• • 7. (7) The patient had any of the following conditions in the 12 months before surgery: myocardial infarction, severe/unstable angina pectoris, coronary artery bypass grafting, congestive heart failure, cerebrovascular accident, pulmonary embolism
• • 8. (8) Pregnant women
• • 9. (9) Unable to cooperate with follow-up or poor compliance
• • 10. (10) Patients with acute myocardial infarction, cardiac arrest or shock during surgery or hospitalization
• • 11. (11) ASA score above grade III.