Nephroprotective Effect of Nicorandil in Type 2 Diabetes Mellitus

Launched by TANTA UNIVERSITY · May 21, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the effects of a medication called nicorandil on kidney health in people with type 2 diabetes. Researchers want to find out if nicorandil can help protect the kidneys from damage caused by diabetes. The trial is currently looking for participants who are between 18 and 60 years old, have been newly diagnosed with type 2 diabetes, and have good blood sugar control. It’s important that participants also have early stages of chronic kidney disease (CKD) and controlled high blood pressure.

If you decide to join the study, you will be monitored closely to see how nicorandil affects your kidney function. However, certain individuals cannot participate, such as pregnant women, those who are sensitive to nicorandil, or those with other specific health conditions that could affect the results. This trial is a great opportunity for eligible individuals to contribute to important research that may improve kidney care for people with diabetes in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients newly diagnosed with T2DM with diet control and good glycemic index ( Hb A1C\< 7 )
• • Age range between 18 and 60 years old.
• • Both sexes.
• • Stage 1and Stage 2 CKD according to KDIGO .
• • Controlled HTN .
• Exclusion Criteria:
• • Pregnant and lactating females.
• • Patients with hypersensitivity to nicorandil.
• • Other Causes of CKD or Nephropathy eg : Uncontrolled HTN , Renal Malignancy , collagen disease as Amyloidosis and some autoimmune disease as ( SLE and Rh.fever ) .
• • Uncontrolled HTN and its antihypertensive medications ( ACEI , ARB ) and other antihypertensive medications .
• • Patients receiving nephrotoxic drugs as aminoglycosides, non-steroidal anti inflammatory drugs and contrast media.