Bioavailability and Bioactivity of Orange Polyphenols

Launched by UNIVERSITY OF ULSTER · May 22, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how consuming oranges can affect our health, especially gut health. Oranges are packed with beneficial compounds called polyphenols, which are known to be good for us, but we don't fully understand how they work in our bodies. This study aims to learn more about how well our bodies absorb and use the polyphenols from oranges, which could help create new healthy food products in the future.

To be eligible for this trial, participants must be between 18 and 75 years old and have either had an ileostomy for at least 1.5 years or be healthy adults with no chronic diseases. Participants should not be pregnant, taking certain medications, or have any allergies to citrus fruits. If you join the trial, you can expect to take part in research that could lead to better understanding of nutrition and health, and you'll be contributing to important discoveries about how the foods we eat affect our well-being.

Gender

ALL

Eligibility criteria

• • Inclusion Criteria: (ileostomates)
• • Adult with an ileostomy, ≥1.5-years post-operative
• • Aged 18-75 years at recruitment
• • Not pregnant / lactating
• • No learning or other disabilities
• • Not currently taking antibiotics
• • Not currently taking plant-based dietary supplements
• • Not currently taking any prescribed medications that would prevent overnight fasting
• • Inclusion Criteria Healthy adults; no pre-existing chronic disease (GI related)
• • Aged 18-75 years at recruitment
• • Not pregnant / lactating
• • No learning or other disabilities
• • Not currently taking antibiotics
• • Not currently taking plant-based dietary supplements
• • Not currently taking any prescribed medications that would prevent overnight fasting
• Exclusion criteria (Ileostomates):
• • Adults \<18 or \>75 years at recruitment
• • Ileostomy, \<1.5 years post-operative
• • Pregnant/lactating females
• • Adults with learning or other disabilities
• • Citrus fruit (orange) allergy or sensitivity
• • Currently taking antibiotics
• • Currently taking plant-based dietary supplements
• • Currently taking any prescribed medications that would prevent overnight fasting
• Exclusion criteria (Healthy adults):
• • Adults \<18 or \>70 years at recruitment
• • Pregnant/lactating females
• • Adults with learning or other disabilities
• • Citrus fruit (orange) allergy or sensitivity
• • Currently taking antibiotics
• • Currently taking plant-based dietary supplements
• • Currently taking any prescribed medications that would prevent overnight fasting