Hemodynamic Impact of the Administration of PAracetamol in Patients Hospitalized in the Intensive Resuscitation Medicine Department [PAREA]

Launched by CENTRE HOSPITALIER UNIVERSITAIRE DE NICE · May 21, 2024

Keywords

ClinConnect Summary

The PAREA trial is studying how the use of paracetamol, a common pain reliever and fever reducer, affects blood pressure in patients who are in the Intensive Care Unit (ICU). Previous research has suggested that giving paracetamol through an IV might cause low blood pressure, but there isn't enough information about this. This study aims to find out how often significant low blood pressure happens within an hour after receiving paracetamol, either through an IV or by mouth, and what other factors, like age or weight, might be related to this issue.

To be eligible for this trial, participants need to be at least 18 years old, have an arterial catheter (a tube used to measure blood pressure), and have a doctor's order for paracetamol. However, certain people cannot participate, such as those who are pregnant, have allergies to paracetamol, or do not want their health information collected. If someone is part of the study, they can expect to be monitored for any changes in their blood pressure after receiving paracetamol, helping researchers understand its effects better.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Inclusion:
• • 18 years of age or older
• • Patient with arterial catheter
• • Indication of paracetamol's administration by the patient's attending practitioner.
• • No opposition to patient or support person participation in the study if the patient is unable to participate
• ExclusionCriteria:
• • No Social Security Patient
• • Pregnant or nursing patient.
• • Patient with a legal protection measure
• • Hypersensitivity and/or allergy to paracetamol.
• • Contraindication to the use of paracetamol.
• • Patient opposition to health data collection.