RAPID-POP a Randomized Controlled Trial

Launched by NATIONAL INSTITUTE OF CARDIOVASCULAR DISEASES, PAKISTAN · May 23, 2024

Keywords

ClinConnect Summary

The RAPID-POP clinical trial is studying a new method called the Pressure Optimization Protocol (POP) for placing heart stents during a procedure known as primary percutaneous coronary intervention (PCI). This trial aims to see if using higher pressure and keeping the stent in place for a longer time can lead to better blood flow in the heart compared to the usual method of quickly inflating and deflating the stent. The researchers hope that this new approach will result in fewer complications, like slow blood flow, and better overall heart function.

To participate in this trial, you need to be at least 18 years old and undergoing a heart procedure where a stent is needed to open a blocked artery. The trial is open to all genders, but people with severe heart failure, certain serious health conditions, or prior heart surgery may not be eligible. If you join, you can expect close monitoring during the procedure and follow-up to see how well your heart is doing afterward. This trial is currently recruiting participants, and your involvement could help improve heart treatment for others in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients aged 18 years and above.
• • Patients undergoing primary percutaneous coronary intervention (PCI) with stent implantation.
• • Presence of significant coronary artery stenosis (greater than 70% diameter reduction) confirmed by angiography.
• Exclusion Criteria:
• • Patients with Killip class IV
• • Patients with significant comorbidities such as end-stage renal disease or advanced liver disease which may interfere with the procedure or follow-up.
• • Prior history of coronary artery bypass grafting (CABG).
• • Refusal to give consent for study participation or procedure