Group B Strep Correlates of Protection Study

Launched by UNIVERSITY OF WITWATERSRAND, SOUTH AFRICA · May 23, 2024

Keywords

ClinConnect Summary

Observational Case-Control Study

* A cohort of 15,000 mother-infant dyads will be enrolled at Chris Hani Baragwanath Academic Hospital (n=10,000) and Rahima Moosa Mother and Child Hospital(n=5,000) over an 18-24-month period, anticipated to start in the first quarter of 2019.
* Enrolment into the cohort study will occur at antenatal clinic, during the early stages either of labour or immediately post-delivery.
* In parallel, enrolment of GBS cases will occur at the time of diagnosis of invasive GBS disease. These "retrospective cases" will be enrolled at multiple facilities across South Af...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Pregnant women attending for antenatal care at one of the participating antenatal-clinics and/or delivering at CHBAH or RMMCH.
• • 2. Subjects aged ≥18 years.
• • 3. Able to understand and comply with planned study procedures.
• • 4. Provides written informed consent.
• Exclusion Criteria:
• • 1. Refusal to consent to study participation.
• • 2. Receipt of any blood products in the past 4 weeks or anticipated during labour.