A Model for Drug Concentration Prediction of Vancomycin

Launched by PEKING UNION MEDICAL COLLEGE HOSPITAL · May 27, 2024

Keywords

ClinConnect Summary

Background: Vancomycin is a glycopeptide antibiotic primarily used to treat infections caused by methicillin-resistant Staphylococcus aureus (MRSA). As a time-dependent antibiotic, the serum concentration of vancomycin is closely related to the clinical efficacy, toxicity and emergence of drug resistance. Therefore, therapeutic drug monitoring (TDM) is considered an important component of vancomycin treatment management. According to vancomycin surveillance guidelines, It is recommended to maintain a serum vancomycin concentration of 15-20 mg/L in patients with severe infections in order to...

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Eligibility criteria

• Inclusion Criteria:
• • Age ≥18 years;
• • Patients admitted to ICUs;
• • Patients were administered intravenous vancomycin;
• • Vancomycin TDM was performed at least two times.
• Exclusion Criteria:
• • Vancomycin TDM was performed in a ward rather than in an ICU;
• • Patients with missing data.

Trial Officials