A Model for Drug Concentration Prediction of Vancomycin

Launched by PEKING UNION MEDICAL COLLEGE HOSPITAL · May 27, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how to better predict the levels of a medication called vancomycin in the blood of critically ill patients. Vancomycin is often used to treat serious infections, but getting the right amount in the body is important for it to work effectively and safely. The researchers aim to use advanced computer techniques, known as machine learning, to develop a model that can accurately forecast how much vancomycin is needed for patients in intensive care units (ICUs).

To participate in this study, patients must be at least 18 years old, have been admitted to the ICU, and have received intravenous vancomycin treatment. They also need to have their vancomycin levels checked at least twice. The researchers will look at data from patients treated at Peking Union Medical College Hospital and will also verify their findings using another large medical database. This study has been approved by the hospital's ethics committee, ensuring that it meets safety and ethical standards.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥18 years;
• • Patients admitted to ICUs;
• • Patients were administered intravenous vancomycin;
• • Vancomycin TDM was performed at least two times.
• Exclusion Criteria:
• • Vancomycin TDM was performed in a ward rather than in an ICU;
• • Patients with missing data.