Fundus Optical coheRence Tomography Angiography Evaluation for Small-vessel Health in Cerebral Small Vessel Disease

Launched by ZHEJIANG PROVINCIAL PEOPLE'S HOSPITAL · May 27, 2024

Keywords

ClinConnect Summary

The clinical trial titled "Fundus Optical coheRence Tomography Angiography Evaluation for Small-vessel Health in Cerebral Small Vessel Disease" is studying a condition called cerebral small vessel disease (CSVD), which can lead to serious issues like stroke and dementia, particularly in people over the age of 60. The trial is exploring a new imaging technology called optical coherence tomography angiography (OCTA), which allows doctors to take detailed pictures of the eye's blood vessels without needing to perform surgery. The aim is to see if the changes in these eye images can help identify and understand the effects of CSVD on the brain.

To participate in this study, individuals must be at least 35 years old and have already undergone specific brain scans that show signs of CSVD. Those who have certain eye diseases or serious health issues that could affect the study will not be eligible. Participants can expect to undergo non-invasive eye imaging and contribute to research that may improve the understanding and management of cerebral small vessel disease. This trial is actively recruiting participants, and everyone is welcome, regardless of gender.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Older than 35 years old;
• • 2. Patients who underwent Multimodal MRI with any CSVD imaging marker;
• • 3. Subjects who have signed informed consent.
• Exclusion Criteria:
• • 1. Patient who was unable to cooperate with examinations;
• • 2. There are known diseases that may cause or worsen CSVD (brain injury, Down syndrome, Alzheimer's disease, Parkinson's disease, etc.);
• • 3. There are known eye diseases or severe underlying fundus lesions that may impact fundus assessment;
• • 4. Suffering from serious systemic diseases, such as heart, liver, kidney diseases or major mental illnesses;
• • 5. Contraindications for imaging examinations
• Exit Criteria:
• • 1. Not meet the inclusion criteria.
• • 2. For any poor adherence, not comply with the requirements of the follow-up, or safety reasons determined by investigator.
• • 3. Any adverse or serious adverse events during the study period judged by investigator