Trials
Search / Trial NCT06431958

Droplet Digital PCR and PCR-free BIOSensors for the Detection of Resistance-associated SNPs in Pneumocystis Jirovecii

Launched by UNIVERSITY HOSPITAL, BREST · May 22, 2024

Apply for Trial

Trial Information

Current as of March 14, 2025

Active, not recruiting

Keywords

Pneumocystis Jirovecii Mutant Anti Microbial Resistance Dhps Dhfr Cytochrome B Impdh

ClinConnect Summary

Pneumocystis jirovecii (P. jirovecii) is an opportunistic pathogenic fungus responsible for pulmonary infection or Pneumocystis pneumonia (PCP) in immunocompromised patients. There is currently no system for its in vitro culture. The diagnostic methods used are mainly based on molecular biology techniques which also allow the detection and analysis of single nucleotide polymorphisms (SNPs), particularly at the level of genes coding for the targets of molecules widely used in the prevention and treatment of PCP. These SNPs may represent missense mutations potentially associated with treatmen...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • • Patients in whom P. jirovecii was detected in a pulmonary sample (bronchoalveolar lavage, sputum, bronchial aspiration, oropharyngeal rinse, nasopharyngeal sample)
  • • No opposition
  • • Patient affiliated to a social security system
  • Exclusion Criteria:
  • • Patients under legal protection (guardianship, curatorship)
  • • Refusal to participate

About University Hospital, Brest

The University Hospital of Brest is a leading academic medical center dedicated to advancing healthcare through innovative clinical research and comprehensive patient care. With a strong emphasis on interdisciplinary collaboration, the hospital serves as a hub for cutting-edge clinical trials aimed at improving treatment outcomes across various medical specialties. Leveraging its robust academic affiliations and state-of-the-art facilities, the University Hospital of Brest is committed to fostering scientific discovery and enhancing the quality of life for patients through evidence-based practices and pioneering research initiatives.

Locations

Brest, , France

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0