3D Printed Custom Applicators for HDR BT (DISCO)

Launched by ROYAL NORTH SHORE HOSPITAL · May 21, 2024

Keywords

ClinConnect Summary

This clinical trial, named DISCO, is exploring a new way to treat gynecologic cancers, such as endometrial, vaginal, and vulva cancers, using specially designed 3D-printed applicators. These applicators help deliver targeted radiation therapy directly to the cancerous areas, which may improve the treatment's effectiveness. The study is currently recruiting female patients aged 65 to 74 who are eligible for a type of therapy called intracavitary brachytherapy, which involves placing a radioactive source close to the tumor.

To participate, patients must be able to provide informed consent and have specific types of gynecologic cancers that are at certain stages. They should also have a good overall health status, as defined by certain criteria. Participants in the trial will receive treatment using these custom applicators and will help researchers understand if this method is a feasible option for future cancer care. It's important to note that some patients, such as those who are pregnant or have certain medical conditions, may not be eligible to join the study.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Able to give informed consent
• • Patients indicated for intracavitary brachytherapy
• • FIGO stage I-IVA
• • ECOG 0-2
• • Primary endometrial cancer, primary vaginal cancer, primary vulva cancer, recurrent gynaecological cancer
• Exclusion Criteria:
• • Pregnancy
• • Patients contraindicated for brachytherapy
• • Inflammatory bowel disease/history of adhesions/bowel obstruction
• • Renal transplant/horseshoe kidney
• • Patients with significant LVSI or pelvic sidewall invasion
• • Patients requiring interstitial brachytherapy implants