Evaluation of Butyrate and Palmitoylethanolamide in IBS Patients (B/P3_1)

Launched by UNIVERSITY OF PADOVA · May 21, 2024

Keywords

ClinConnect Summary

Ulcerative colitis (UC) is a chronic inflammatory condition affecting the colon, characterized by relapsing and remitting mucosal inflammation. It presents with symptoms like bloody diarrhea, rectal urgency, fatigue, and abdominal pain. While various therapies are available for managing UC, including medications like amino salicylates, corticosteroids, immunomodulators, and biologics, there's ongoing research into supportive treatments like probiotics.

Probiotics are beneficial microorganisms that can positively influence gut health by modifying the gut microbiota, improving intestinal bar...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • ● IBS patients (both males and females) with positive diagnosis based on Rome IV criteria (IBS-D and IBS-M)
• • Age in the range 18-70 years
• • Subjects capable of conforming to the study protocol
• • Subjects who have given their free and informed consent
• Exclusion Criteria:
• • -Any relevant organic, systemic or metabolic disease, including celiac disease, IDDM (Insulin- Dependant Diabetes Mellitus), Insulin-Independent Diabetes Mellitus, metabolic syndrome, pelvic organ prolapses, urinary incontinence, ulcerative colitis, Crohn's disease, microscopic colitis, infectious colitis, ischemic colitis, complicated diverticular disease.
• • Subjects with untreated food intolerance, i.e. remaining symptomatic despite the withdrawal of the suspected food
• • Prior major gastrointestinal surgeries
• • Females of childbearing potential, in the absence of effective contraceptive methods
• • Subjects who become unable to conform to protocol
• • Subjects who are continuously taking contact laxatives
• • Subjects who are treated continuously with glucocorticoids, anti-histaminergic and mast cell stabilizer drugs
• • Subjects who are treated continuously with trimebutine
• • Recent history or suspicion of alcohol abuse or drug addiction
• • Subjects who are treated with antibiotics or probiotics