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Search / Trial NCT06432686

Neurophysiological Effects of Transcutaneous Electrical Nerve Stimulation in Persons With MS

Launched by UNIVERSITY MEDICAL CENTER GRONINGEN · May 22, 2024

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Trial Information

Current as of February 12, 2025

Not yet recruiting

Keywords

ClinConnect Summary

This study is an exploratory study to see if we can detect changes in fMRI activity during TENS in persons with MS. This is a randomized, single-blind crossover design. Subjects will undergo an MRI scan while they receive sham stimulation of the tibialis anterior, active stimulation of the tibialis anterior, stimulation of the quadriceps, perform continuous movements of the foot (plantar \& dorsiflexion) and a combination of stimulation of the tibialis anterior and movement of the foot. This study will include 15 subjects with relapsing remitting or progressive MS and 15 healthy controls. B...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • • age: 18-65 years
  • • EDSS score \< 7
  • Exclusion Criteria:
  • • metal or electrical implants
  • • BMI \> 40
  • • claustrophobia
  • • being pregnant
  • • having a psychiatric disorder
  • • having cognitive or communication problems which reduces the capacity to understand instructions
  • • having a neurological disorder other than MS
  • • having cardiac arrhythmia

About University Medical Center Groningen

University Medical Center Groningen (UMCG) is a leading academic medical center in the Netherlands, renowned for its commitment to innovative research, high-quality patient care, and extensive education in the medical field. As a prominent sponsor of clinical trials, UMCG leverages its multidisciplinary expertise and state-of-the-art facilities to advance medical knowledge and improve therapeutic outcomes. The center fosters collaboration among researchers, healthcare professionals, and industry partners, aiming to translate scientific discoveries into effective treatments that enhance patient health and well-being. With a focus on ethical standards and regulatory compliance, UMCG is dedicated to conducting clinical trials that contribute to the advancement of medicine and the betterment of society.

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Estimated completion

Not reported

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