Understanding the Efficacy of Dietary Supplement on Fungal Mycobiota in Healthy Volunteers: A Pilot Study

Launched by WEILL MEDICAL COLLEGE OF CORNELL UNIVERSITY · May 22, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating how a dietary supplement called L-Phenylalanine affects gut health, specifically looking at its impact on a substance called phenylpropionic acid (PPA) and the types of fungi present in the gut. Researchers want to understand if taking this supplement can change the balance of these fungi, which may play a role in overall gut health.

To participate in the study, you need to be an adult over 18 years old and generally healthy. However, if you have a history of gut-related issues or have recently taken certain medications like antibiotics or antifungal treatments, you may not be eligible. Participants will take the dietary supplement and monitor any changes in their gut microbiome, which is the community of microbes living in the digestive system. This study is currently recruiting, and it’s a great opportunity to contribute to our understanding of gut health!

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male or female adults over the age of 18 years
• Exclusion Criteria:
• • History of a diagnosis of any gastrointestinal condition, such as inflammatory bowel syndrome or disease
• • Antibiotic usage within the past two weeks
• • Antifungal usage within the past month
• • Allergy to L-Phenylalanine or individuals with phenylketonuria (PKU)
• • Adults taking medications known to interact with L-phenylalanine supplements, such as Monoamine Oxidase Inhibitors (MOAI), L-DOPA, and some antipsychotic drugs (complete and extensive drug list will be provided to interested participants during screening)
• • Pregnant or nursing women