BEst Size for Ovulation Triggering in Poseidon 4 Patients (BEST 4 Study)

Launched by CENTRUM CLINIC IVF CENTER · May 23, 2024

Keywords

ClinConnect Summary

The BEST 4 Study is a clinical trial designed to find the best timing for triggering ovulation in women aged 35 and older who have a low number of healthy eggs. The study will look at two groups of women undergoing treatment to help them conceive. One group will receive the ovulation trigger when their egg follicles are between 13-16 mm in size, while the other group will receive it when their follicles are larger than 17 mm. All participants will receive the same medication to help trigger ovulation, and the main goal of the study is to see how many mature eggs each group produces.

To be eligible for this study, women must be over 35 years old, have low hormone levels indicating a reduced ovarian reserve, and be undergoing specific fertility treatments. Women with certain health issues or those who have had previous surgeries may not be eligible. Participants can expect to contribute to important research that may improve fertility treatments for women facing similar challenges. The study is not yet recruiting participants, but it aims to gather valuable information on how timing affects egg development and fertilization.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Women age \>35 years Women with low serum AMH (\<1,2 ng/ml), low AFC (\<5) Undergoing assisted reproduction with Short antagonist protocol Max daily gonadotropin dose of 300 IU
• Exclusion Criteria:
• • women with uterine and/or endometrial abnormality, women with endometrioma(s), short or long GnRH-agonist ovarian stimulation protocols, severe male infertiliy, genetic conditions, with normal ovarian reserve markers, \<35 years old, women with prior ovarian surgeries, PGT-a cycles