SARS-CoV-2 Specific Antibody Responses and Impact for COVID-19 Disease in Ethiopia

Launched by MICHAEL HOELSCHER · May 24, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how the body responds to the SARS-CoV-2 virus, which causes COVID-19, in healthcare workers and the general population in Ethiopia. Researchers want to understand how well people’s immune systems protect them against COVID-19 after they have been infected or vaccinated. Participants will be monitored for up to two years to see how their antibody levels change over time and how this relates to any COVID-19 illnesses they may experience, especially in those who have already been exposed to the virus or vaccinated.

To be eligible for this study, participants must be adults aged 18 or older, be willing to provide consent, and work in a hospital setting. They also need to be open to giving blood samples for testing and sharing health information. During the trial, participants can expect to provide blood samples and report any health changes. The study will help researchers learn more about how the immune system responds to different strains of the virus and may influence future vaccination strategies.

Gender

ALL

Eligibility criteria

• Inclusion criteria:
• • 1. Adults, 18 years of above
• • 2. Provision of oral as well as written informed consent
• • 3. Available estimation of the period or the time-point when SARS-CoV-2 infection occurred (e.g. confirmed or highly suspected COVID-19 disease, SARS-CoV-2 anti-nucleocapsid seroconversion) (only applicable for participants included in group 1 and 2).
• • 4. Employed/working in hospital (medical doctors, nurses/midwives, students, auxiliary personnel such as cleaner, runner, social worker) for HCW
• • 5. Willingness to provide blood samples by venipuncture for serology and immunological characterization
• • 6. Willingness to provide health information, report medical events and to performed SARS-CoV-2 diagnostics (swabs for PCR) in the case of suspected COVID-19 disease
• Exclusion criteria:
• • 1. Prisoners
• • 2. Mentally disturbed persons
• • 3. Persons for whom study participation will induce an unacceptable risk or burden as judged by the investigator (e.g. seriously sick persons)