Biocollection of Rare Pediatric-onset of Autoimmune and Autoinflammatory Diseases

Launched by HOSPICES CIVILS DE LYON · May 24, 2024

Keywords

ClinConnect Summary

This clinical trial is focused on understanding rare autoimmune and autoinflammatory diseases that often begin in childhood, such as systemic lupus and juvenile arthritis. These diseases can be quite severe and are usually linked to genetic factors. The goal of the trial is to create a collection of biological samples, including blood and DNA, from patients and healthy volunteers. This collection will help researchers identify genetic and immune system problems related to these rare diseases, which can improve diagnosis and treatment options in the future.

To participate in this study, you or your child must have a rare autoimmune disease that started before the age of 18 or be a relative of someone who does. Healthy volunteers can also join, as long as they meet certain criteria, such as not having any active infections or a history of autoimmune diseases. Everyone involved will need to sign a consent form after being informed about the study. Participants can expect to provide biological samples, which will be used for research aimed at better understanding these conditions. This study is currently recruiting participants of all ages, so if you think you might qualify, it could be a valuable opportunity to contribute to important research.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients
• • minor or adult patient of any age with a rare dysimmune disease characterized by autoimmunity or auto-inflammation or early lymphoproliferation, having started in childhood (\<18 years), or syndromic or familial
• • relative of a minor or adult patient with a rare dysimmune disease characterized by autoimmunity or auto-inflammation or early lymphoproliferation, having started in childhood (\<18 years of age) or syndromic or familial,
• • weight greater than 5 kg
• • Patient/parents/guardians who were informed of the study and signed the consent form.
• • patient affiliated to a social security scheme
• • Healthy volunteer participants
• • minor or adult participants with no age restrictions
• • weight over 5 kg
• • Subject /Parents/guardians who were informed of the study and signed a consent form.
• • Patient affiliated to a social security scheme
• Exclusion Criteria:
• • Patients
• • - Subjects /Parents/guardians, refusing to participate in the study
• Healthy volunteer participants :
• • active infection (viral, bacterial, parasitic)
• • history of neoplasia (\< 5 years) or current neoplasia
• • participants with a personal or family history of autoimmune disease
• • immunocompromised participant (immune deficiency or transplant recipient)
• • Subjects/parents/guardians refusing to participate in the study
• • Adults under legal protection (guardianship, curatorship)