Evaluations of the Effects of Tranexamic Acid and Chlorhexidine Gel on Alveolar Osteitis Incidence

Launched by RECEP TAYYIP ERDOGAN UNIVERSITY · May 24, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the effects of two different treatments—tranexamic acid and chlorhexidine gel—on a condition called alveolar osteitis, which can occur after a tooth extraction. Alveolar osteitis, also known as dry socket, happens when the blood clot that forms in the empty tooth socket becomes dislodged or does not form properly, leading to pain and other complications. The trial involves healthy adults aged 18 to 65 who need molar or premolar teeth extracted. Participants will be randomly assigned to receive one of three treatments after their tooth extraction: a special sponge, a sponge with chlorhexidine gel, or a sponge with tranexamic acid.

During the trial, participants can expect to visit the clinic for check-ups on the 3rd and 7th days after their extraction, where their pain and swelling will be assessed using a simple scale from 0 to 10. The researchers will also look for signs of complications, such as bad breath or difficulty opening the mouth. It’s important to note that people with certain allergies, recent infections, or other specific health conditions cannot participate in this study. This trial is ongoing and is not currently recruiting new participants.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Healthy individuals between the ages of 18-65
• • 2. Molar and premolar teeth with extraction indication
• Exclusion Criteria:
• • 1. Against drugs or substances to be used in surgery (articaine, tranexamic acid, chlorhexidine) have allergies,
• • 2. Those who used antibiotics 30 days before the dental extraction,
• • 3. Clinical and radiological examinations in the operation area 30 days before dental extraction and/or on the day of the procedure.
• • Any signs of pathology and infection (such as periapical pathology, pericoronitis),
• • 4. Those who routinely use oral antiseptics,
• • 5. Systemic fever, absence of growth such as lymphadenopathy (LAP),
• • 6. Women are lactating or pregnant,
• • 7. Using oral contraceptives,
• • 8. Procedures that were not attended to control appointments (day 3-7) were not included.