Effect of Oxycodone on Anxiety State in Painless Abortion

Launched by RUIJIN HOSPITAL · May 24, 2024

Keywords

ClinConnect Summary

This study is a multicenter, randomized controlled clinical study. A total of 300 patients who underwent elective painless abortion surgery in Ruijin Hospital and other sub-central hospitals were enrolled, and they were randomly divided into 1:1 patients who received intravenous anesthesia with propofol with fentanyl (group F) and propofol with oxycodone (group O). The scores of anxiety, depression and postoperative numerical rating scale (NRS) before and after surgery were observed, and the levels of serum stress response factors and inflammatory cytokines were monitored. The effects of ox...

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Age 18-45 years old
• • Gestational age 6-12 weeks
• • American Society of Anesthesiologists （ASA） Grading I-II
• • Fluent communicator and able to complete self-rating scales on her own
• • Voluntarily participate and sign the informed consent form
• Exclusion Criteria:
• • Patients who are allergic to anesthetic drugs such as propofol, oxycodone, fentanyl, etc., or who have had other anesthetic adverse events
• • Patients with anxiety or depression
• • Presence of organic mental disorders, mental retardation
• • Severe acute and chronic infection, severe heart, liver and kidney insufficiency
• • Patients with complications or bleeding \> 50ml during surgery