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Search / Trial NCT06436027

Molecular Diagnosis of Heart Allograft Rejection Using Intra-Graft Targeted Gene Expression Profiling.

Launched by PARIS TRANSLATIONAL RESEARCH CENTER FOR ORGAN TRANSPLANTATION · May 28, 2024

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Trial Information

Current as of March 14, 2025

Completed

Keywords

Molecular Biology Allograft Rejection Endomyocardial Biopsy Pathology Precision Diagnosis Heart Transplantation

ClinConnect Summary

Heart transplantation (HTx) remains the most valuable therapeutic option for patients with end-stage heart failure refractory to optimal medical therapy. Despite major improvements in immunosuppression and transplant care, acute and chronic rejection-induced allograft injuries remain one of the leading causes of mortality and morbidity after heart transplantation, thus limiting recipients' life expectancy. An improvement in the overall management of rejection remains an unmet medical need. As a first step, a precise diagnosis of rejection is crucial to guide patient care and optimize manage...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • • heart transplant recipients ≥ 18 years old
  • • at least one endomyocardial biopsy performed as part of routine clinical care
  • • biopsy performed at least ≥ 1 month post transplant and less that 10-year post-transplant
  • • written informed consent
  • Exclusion Criteria:
  • • age below 18 years old

Trial Officials

Alexandre Loupy, MD, PhD

Study Director

Paris Translational Research Center for Organ Transplantation

Guillaume Coutance, MD, PhD

Principal Investigator

Paris Translational Research Center for Organ Transplantation

About Paris Translational Research Center For Organ Transplantation

The Paris Translational Research Center for Organ Transplantation is a leading clinical trial sponsor dedicated to advancing the field of organ transplantation through innovative research and collaborative efforts. Committed to bridging the gap between laboratory discoveries and clinical applications, the center focuses on improving transplant outcomes, enhancing patient care, and developing novel therapeutic strategies. With a multidisciplinary team of experts, the center fosters a rigorous research environment that promotes scientific excellence and ethical standards, ultimately aiming to transform the landscape of organ transplantation and provide hope for patients in need of lifesaving procedures.

Locations

Los Angeles, California, United States

Paris, , France

Padova, , Italy

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0