Kidney Stone Inflammation

Launched by UNIVERSITY OF CHICAGO · May 29, 2024

Keywords

ClinConnect Summary

This clinical trial, called "Kidney Stone Inflammation," is studying the connection between kidney stones, insulin resistance, and inflammation. Researchers believe that people who develop calcium kidney stones and have insulin resistance might have higher levels of inflammation due to having more visceral fat, which is the fat stored around the organs in the abdomen. The study will involve 40 participants—20 individuals with a history of calcium kidney stones and 20 healthy individuals who have never had kidney stones.

To participate, individuals should be between 18 and 70 years old. Those with kidney stones need to have had at least one calcium-based stone, while healthy participants should not have any history of kidney stones or a family history of them. During the study, participants will visit the University of Chicago Medicine, where they will undergo a scan to measure body fat, provide blood and urine samples, and undergo tests to check for insulin resistance and other factors related to kidney stones. The goal is to understand how these factors are related, which could help identify individuals at risk for kidney stones and lead to better prevention strategies in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• * Stone formers:
• • Age 18-70
• • History of at least one calcium-based kidney stone
• * Healthy Controls:
• • Age 18-70
• • No history of kidney stone or family history of kidney stones
• Exclusion Criteria (for both groups):
• • History of primarily uric acid
• • Cysteine, or struvite stones
• • History of diabetes or impaired glucose tolerance
• • Previous thiazide use
• • Anyone on a medication that cannot be stopped that may affect urine composition
• • Previous bariatric surgery or ileostomy
• • Primary hyperparathyroidism and elevated serum calcium.

Trial Officials