Epidural Stimulation for Upper Extremity Function

Launched by BRIGHAM AND WOMEN'S HOSPITAL · May 30, 2024

Keywords

ClinConnect Summary

The study will enroll up to 20 participants in a single arm prospective clinical study. Potential participants will have already had a nerve transfer surgery more than 6 months prior to enrollment and will have also completed post-nerve transfer physical /occupational neurorehabilitation.

At baseline, upper extremity muscle strength, muscle force and nerve health with needle electromyography and neuroimaging will be tested.

Patients will undergo percutaneous (temporary) spinal cord stimulator leads placement in the cervical supralesional spine region.

Week 0-4: Weekly testing of motor fu...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥18 years and ≤65
• • Provides informed consent
• • History of upper extremity nerve transfer \> 6 months prior to enrollment
• • Completion of standard post-nerve transfer occupational therapy
• • Baseline upper extremity strength of \< 5/5 grade with the MRC
• • Scheduled to undergo a cervical spinal cord stimulation procedure for chronic pain refractory to first line therapy
• • Willing and able to adhere to the study protocol
• Exclusion Criteria:
• • Central nervous system (CNS) malignancy
• • A contraindication to the SCS procedure
• • Diagnosis that precludes the patient from full participation in the protocol
• • A functional implanted device (pacemaker, vagus nerve device, baclofen pump)
• • Botulinum toxin injection in upper extremity muscles \< 6 months prior to enrollment
• • For female participants, current/planned pregnancy (females of childbearing age will be asked to take a pregnancy test on the day of the intervention)
• • Other factors that prevent participation in the opinion of the surgeon-principal investigator

Trial Officials