Trials
Search / Trial NCT06438107

Deep Phenotyping of the Renal Allograft to Prognosticate Clinical Outcomes

Launched by UNIVERSITY OF PITTSBURGH · May 26, 2024

Trial Information

Current as of February 08, 2025

Not yet recruiting

Keywords

Organ Rejection Acute Rejection

ClinConnect Summary

This study is exploratory in nature and aims to elucidate the phenotypic, transcriptional, and epigenetic underpinnings of renal transplant rejection. The study is designed to provide improved understanding of the regulation of intra-graft alloimmune response in the renal transplant recipients.

In this single center, prospective, longitudinal, observational cohort study, sequential assessment of renal biopsies will be performed at baseline (pre-implantation), 3 months and at one-year post-transplantation in addition to any for-cause biopsies within the first five years post-transplantation...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • 1. All adult living or deceased donor renal transplant recipients (age ≥ 18 years), irrespective of gender, race, or ethnic background.
  • 2. Able to understand and provide inform consent.
  • Exclusion Criteria:
  • 1. Medical contraindications to undergo renal biopsy (use of long-term anticoagulation, low platelet count of \<100,000/uL)
  • 2. Cause of ESRD likely to recur in transplant: Hemolytic uremic syndrome (HUS)
  • 3. Not maintained on standard of care immunosuppression therapy (Thymoglobulin induction followed by tacrolimus and mycophenolate maintenance)

Trial Officials

Aravind Cherukuri, MD

Principal Investigator

University of Pittsburgh

About University Of Pittsburgh

The University of Pittsburgh is a leading research institution known for its commitment to advancing medical science and improving patient care through innovative clinical trials. With a robust infrastructure for research and a multidisciplinary approach, the university fosters collaboration among experts in various fields, facilitating the development of novel therapies and interventions. Its clinical trial programs emphasize ethical standards, patient safety, and the integration of cutting-edge technology, making the University of Pittsburgh a pivotal contributor to the landscape of clinical research and a trusted partner in the pursuit of health advancements.

Locations

Pittsburgh, Pennsylvania, United States

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0