Deep Phenotyping of the Renal Allograft to Prognosticate Clinical Outcomes

Launched by UNIVERSITY OF PITTSBURGH · May 26, 2024

Keywords

ClinConnect Summary

This study is exploratory in nature and aims to elucidate the phenotypic, transcriptional, and epigenetic underpinnings of renal transplant rejection. The study is designed to provide improved understanding of the regulation of intra-graft alloimmune response in the renal transplant recipients.

In this single center, prospective, longitudinal, observational cohort study, sequential assessment of renal biopsies will be performed at baseline (pre-implantation), 3 months and at one-year post-transplantation in addition to any for-cause biopsies within the first five years post-transplantation...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. All adult living or deceased donor renal transplant recipients (age ≥ 18 years), irrespective of gender, race, or ethnic background.
• • 2. Able to understand and provide inform consent.
• Exclusion Criteria:
• • 1. Medical contraindications to undergo renal biopsy (use of long-term anticoagulation, low platelet count of \<100,000/uL)
• • 2. Cause of ESRD likely to recur in transplant: Hemolytic uremic syndrome (HUS)
• • 3. Not maintained on standard of care immunosuppression therapy (Thymoglobulin induction followed by tacrolimus and mycophenolate maintenance)

Trial Officials