Parkinsonism-Related Oscillations in the Cortico-Basal Ganglia-Thalamic Network During Movement: Beyond the Frequency Range

Launched by UNIVERSITY HOSPITAL, BORDEAUX · May 27, 2024

Keywords

ClinConnect Summary

This clinical trial is focused on understanding how certain brain activities, called oscillations, affect movement in people with Parkinson's disease (PD). The researchers want to study these brain activities in patients who have undergone a specific type of surgery called subthalamic deep brain stimulation (STN-DBS). They will observe how these oscillations change during different movement challenges while the patients are on medication or receiving stimulation, which might help improve our understanding of the motor symptoms associated with PD.

To be eligible for this study, participants should be between 18 and 75 years old, diagnosed with idiopathic Parkinson's disease, and have had the STN-DBS surgery for less than a year or be candidates for this surgery. Participants should be able to perform a simple motor task and must provide informed consent. The trial is not yet recruiting, so there will be more information available as it progresses. Participants can expect to contribute to important research that could lead to better treatments for movement issues in Parkinson's disease.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male or Female
• • 18 to 75 years-old
• • With idiopathic Parkinson's disease
• • Having a STN-DBS with a PERCEPT™ for less than a year or being candidate for STN-DBS with the PERCEPT™ device (first-implantation)
• • Able to perform the simple motor task
• • Patients covered by a health insurance scheme
• • Giving free, informed, written consent signed by the participant and the investigator.
• Exclusion Criteria:
• • Be incapable of giving consent personally.
• • Be subject to a legal protection measure (curatorship, guardianship) or be placed under judicial protection.
• • Being pregnant or breastfeeding
• • Present a serious and/or decompensated somatic or psychiatric illness.