Parkinsonism-Related Oscillations in the Cortico-Basal Ganglia-Thalamic Network During Movement: Beyond the Frequency Range

Launched by UNIVERSITY HOSPITAL, BORDEAUX · May 27, 2024

Keywords

ClinConnect Summary

To define the link between the characteristics of neuronal oscillations (frequency, amplitude, phase relationship) within the cortico-subcortical network and the movement, we designed a simple motor task of gripping/pulling a lever. The LFPs will be collected at the cortical and subcortical levels (STN) during the motor task using a high-resolution EEG (HR-EEG) and the Percept™ system (Medtronic). Recordings will be realized in four conditions: without pharmacological treatment and without stimulation (Off condition), without pharmacological treatment and during stimulation (DBS condition),...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male or Female
• • 18 to 75 years-old
• • With idiopathic Parkinson's disease
• • Having a STN-DBS with a PERCEPT™ for less than a year or being candidate for STN-DBS with the PERCEPT™ device (first-implantation)
• • Able to perform the simple motor task
• • Patients covered by a health insurance scheme
• • Giving free, informed, written consent signed by the participant and the investigator.
• Exclusion Criteria:
• • Be incapable of giving consent personally.
• • Be subject to a legal protection measure (curatorship, guardianship) or be placed under judicial protection.
• • Being pregnant or breastfeeding
• • Present a serious and/or decompensated somatic or psychiatric illness.