Investigating the Link Between Advanced Glycation End Products (AGEs) and Muscle Wasting in Sarcobesity

Launched by AZIENDA OSPEDALIERO UNIVERSITARIA MAGGIORE DELLA CARITA · May 27, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the relationship between certain substances in our diet called Advanced Glycation End Products (AGEs) and muscle loss in people who are both obese and have type 2 diabetes. Researchers want to see if higher levels of AGEs in the body are linked to greater muscle loss in these patients, which can lead to more serious health issues, including diabetes complications. The study will involve measuring AGE levels in the skin and looking at how these levels relate to the severity of muscle loss in participants.

To be eligible for this trial, participants need to be adults aged 65 to 74, both men and women, who are classified as obese and have well-controlled type 2 diabetes. They should not have certain other health conditions, like inflammatory bowel disease or cancer. If you join the study, you can expect to provide some health information and undergo tests to measure AGEs and assess muscle health. This research aims to better understand how dietary factors contribute to muscle loss and related health problems, which could help in developing ways to improve the health of people facing these challenges.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients of both sexes.
• • Adults.
• • BMI compatible with obesity and a diagnosis of type 2 diabetes under good metabolic control (HbA1c \< 7.5%) within 15 years of entry into the study or diagnosis of lipodystrophy (included in the European Consortium of Lipodystrophies (ECLip) Registry (eclip-web.org))
• Exclusion Criteria:
• • Age under 18 years.
• • Secondary obesity or genetic diseases (Prader-Willi Syndrome, Down Syndrome); metabolic and endocrine disorders (Cushing's syndrome, hypothyroidism).
• • Subjects with: Inflammatory Bowel Disease (IBD), cancer.
• • Confirmed or planned pregnancy during the study participation months.

Trial Officials