MSOT As Non-invasive Biomarker for Diagnosis and Monitoring of Neuromuscular Diseases

Launched by CHILDREN'S HOSPITAL OF EASTERN ONTARIO · May 27, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a new method called Multispectral Optoacoustic Tomography (MSOT) to see if it can help doctors diagnose and monitor neuromuscular diseases (NMDs) in children. NMDs are conditions that affect the muscles and can make it hard for children to move. The researchers want to find out if MSOT scans, which look at muscle tissues and measure things like oxygen levels and fat content, can provide valuable information about how these diseases progress over time. The study will last about 36 months, and participants will have repeated scans to track any changes.

To be eligible for this study, children aged from birth up to 18 years with a confirmed or suspected neuromuscular disease can participate, with consent from a parent or guardian. However, children with certain skin conditions, unstable health issues, or other specific concerns may not be able to join. During the trial, participants will only undergo the MSOT scans, and their results will be compared with other standard medical information already available. This study aims to improve the way doctors diagnose and follow the treatment of neuromuscular diseases in children.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with neuromuscular disease
• • Children (from birth (infants that are born term) to 18 years of age) participants or consent through authorized guardian
• • Confirmed or suspected diagnosis of a neuromuscular disease (through molecular genetics, biopsy, clinical examination)
• Exclusion Criteria:
• Participants:
• • Diagnosis is not consistent with a confirmed or suspected neuromuscular disease
• • Patients with active skin lesions (e.g. infections, trauma) or confirmed genetic disorders (e.g. epidermolysis bullosa) that predisposes to skin lesion
• • Medically unstable patients
• • Tattoo on skin overlying the area to be examined
• • Missing consent form
• • Exclusion due to safety concerns of the investigator (subject who has any condition, including any physical, psychological, or psychiatric condition, which in the opinion of the Investigator, would compromise the safety of the subject or the quality of the data and renders the subject an unsuitable candidate for the study)
• • Medication leading to increased light sensitivity