Trials
Search / Trial NCT06439199

Biological, Prospective Study Evaluating the Dosage of Plasma Cytokines Including the FLT3 Ligand and IL6 of Patients Treated With Non-intensive Chemotherapy

Launched by NANTES UNIVERSITY HOSPITAL · May 31, 2024

Apply for Trial

Trial Information

Current as of March 13, 2025

Recruiting

Keywords

Cytokine Il 6 Flt3 Ligand Aml Cmml Hr Mds Azacytidine

ClinConnect Summary

This clinical trial is studying how certain proteins in the blood, called cytokines, may help doctors understand the treatment outcomes for patients with specific blood cancers, including Acute Myeloid Leukemia (AML), high-risk myelodysplastic syndromes (HR-MDS), and chronic myelomonocytic leukemia (CMML). The researchers want to see if the levels of two particular cytokines, FLT3 ligand and IL-6, in patients receiving a gentler form of chemotherapy can predict how well they respond to treatment and their chances of survival.

To participate in this trial, you must be 18 years or older and have one of the mentioned conditions, either as a first-time treatment or if the disease has come back. You should also be receiving a specific type of medication called a hypomethylating agent, possibly along with another drug. Participants will be asked to provide blood samples and will receive thorough information about the study to ensure they understand what’s involved. It's important to note that pregnant or breastfeeding women, as well as minors, cannot participate in this trial. This study is currently recruiting participants, and joining could help improve the understanding of how to treat these serious conditions better.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria :
  • • Age \>=18 years
  • • AML or SMD-HR or CMML in first line or in relapse receiving a hypomethylating agent +/- another molecule or a hypomethylating agent in combination with venetoclax +/- another molecule.
  • • Patient having agreed to participate in the study (information note signature) and having signed the biocollection consent
  • Exclusion Criteria :
  • • No social security or any other regime
  • • Pregnant women or patient unable to take contraception in case of fertility
  • • Breastfeeding women
  • • Minors
  • • Adults under guardianship, curators or safeguard of justice

About Nantes University Hospital

Nantes University Hospital, a leading academic medical institution in France, is dedicated to advancing healthcare through innovative research and clinical trials. As a prominent sponsor of clinical studies, the hospital integrates cutting-edge scientific exploration with patient care, fostering collaborations among multidisciplinary teams of healthcare professionals and researchers. With a strong emphasis on ethical standards and patient safety, Nantes University Hospital aims to contribute to the development of effective therapies and interventions that enhance patient outcomes and overall public health.

Locations

Nantes, Loire Atlantique, France

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0