Trials
Search / Trial NCT06440044

Recurrence and Bleeding in Colorectal Cancer Patients With Cancer-associated Venous Thrombembolism

Launched by SIXTH AFFILIATED HOSPITAL, SUN YAT-SEN UNIVERSITY · May 28, 2024

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Trial Information

Current as of March 14, 2025

Completed

Keywords

Venous Thrombembolism；Colorectal Cancer；Bleeding

ClinConnect Summary

Patients with colorectal cancer (CRC) have a higher risk of both venous thromboembolism (VTE) and major bleeding (MB). Specifically, a subsequent analysis of the Hokusai study showed that the excess in MB was confined to patients with gastrointestinal cancer. In the RIETE registry, patients with gastrointestinal or genitourinary cancers experienced more bleeding outcomes while patients with brain or lung cancer experienced more thrombotic outcomes. However, in a subgroup analysis of the Caravaggio trial, major gastrointestinal bleeding in patients with CRC was low and similar in both apixab...

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • • 1. Patients with histologically confirmed CRC and symptomatic or incidental VTE who received anticoagulant treatment.
  • • 2. CRC patients with VTE treated with an anticoagulant (rivaroxaban or LMWH) for at least six months.
  • Exclusion Criteria:
  • • 1. Participation in this study required active anticoagulant treatment. Apart from this, there were no specific exclusion criteria.

Trial Officials

xiaoyan li

Principal Investigator

Sixth Affiliated Hospital, Sun Yat-sen University

About Sixth Affiliated Hospital, Sun Yat Sen University

The Sixth Affiliated Hospital of Sun Yat-sen University is a leading medical institution in China, dedicated to advancing healthcare through innovative clinical research and patient-centered care. As a prominent academic hospital, it integrates clinical practice with research excellence, fostering collaboration among multidisciplinary teams to enhance medical knowledge and improve patient outcomes. The hospital is committed to conducting rigorous clinical trials that adhere to the highest ethical standards, aiming to contribute to the global scientific community and support the development of new therapies and interventions. With a focus on translational medicine, the Sixth Affiliated Hospital actively engages in pioneering studies that address critical health challenges and promote evidence-based practices in diverse medical fields.

Locations

Guangzhou, Guangdong, China

People applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

Discussion 0