Treatment of Tempromandibular Joint Anterior Disc Displacement With Different Materials

Launched by MANSOURA UNIVERSITY · May 29, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating how effective two different treatments are for people suffering from a specific jaw condition called anterior disc displacement with reduction (ADDWR). The treatments being compared are injections of platelet lysate, which is derived from your own blood, and hyaluronic acid, a substance commonly used to relieve joint pain. The goal is to see which treatment helps reduce pain and improve jaw function better after a procedure called arthrocentesis, which involves cleaning out the joint.

To participate in this study, you must be diagnosed with ADDWR through a physical exam and an MRI scan, and you should not have found relief from previous conservative treatments. Participants should be experiencing pain in their jaw joints, have normal or limited mouth opening, and may have a clicking sound when moving their jaw. However, you won't be eligible if you've had certain surgeries on your jaw, have specific health conditions, or are taking certain medications. If you join, you can expect to receive one of the treatments and be monitored for how well it works in easing your symptoms. The trial is currently recruiting patients aged 18 to 75, and both men and women can participate.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients that will be diagnosed with anterior disc displacement with reduction (ADDWR) both clinically and through magnetic resonance imaging scan (MRI).
• • Patients who will not respond to a previous conservative therapy.
• • Patients with pain in temporomandibular joints.
• • Patients with normal or limitation in mouth opening.
• • Patients with clicking sound.
• Exclusion Criteria:
• • Patients with previous invasive TMJ surgical procedures.
• • Patients with inflammatory or connective tissue diseases.
• • Patients with neurologic disorders.
• • Patients with history of bony or fibrous adhesion.
• • Patients having gross mechanical restrictions and condylar fractures.
• • Patients with psychological problems.
• • Patients receiving anti-coagulation treatment, non-steroidal anti-inflammatory drugs within 48 hours pre-operatively, corticosteroid injection at the treatment site within one month or systemic use of corticosteroids within 2 weeks.