Differentiating the Invasiveness of Lung Adenocarcinoma by Dual Energy CT Parameter

Launched by TANG-DU HOSPITAL · May 28, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a new way to help doctors determine how serious lung adenocarcinoma, a type of lung cancer, is by using a special imaging technique called dual energy computed tomography (DECT). The main goal is to see if measuring something called the extracellular volume (ECV) can help tell the difference between less serious, precancerous conditions and early-stage lung cancer. This information could guide doctors in making better decisions about whether surgery is needed and how to plan that surgery.

To participate in this study, individuals must be at least 18 years old and have small lung nodules (growths in the lung) that are 3 centimeters or smaller, confirmed to be lung adenocarcinoma. Participants should not have a history of other types of cancer or have undergone treatments like chemotherapy or radiation before the DECT scan. During the study, participants will undergo a contrast-enhanced DECT scan, which involves a special dye that helps improve the images of the lungs. The trial is currently recruiting participants, and it's important to note that individuals with certain allergies or health conditions may not be eligible. This research could lead to better ways to diagnose and treat lung cancer in the future.

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Eligibility criteria

• Inclusion Criteria:
• • patients older than 18 years old with pulmonary nodules (diameter≤3 cm).
• • pathologically confirmed as lung adenocarcinoma.
• • without history of other malignancies.
• • accurate hematocrit within 1 week before contrast enhanced dual energy CT examination.
• Exclusion Criteria:
• • with a history of allergy to iodine contrast agents and other reasons who are unable to complete the examination.
• • without histopathology of invasion stage, such as AAH, AIS, MIA and IAC.
• • history of chemotherapy, radiotherapy, or other anti-tumor therapy before contrast enhanced dual energy CT.
• • poor image quality.
• • contrast enhanced dual energy CT scans ≥ 4 weeks before surgery.