Average Volume-assured Pressure Support as Rescue Therapy in Obesity Hypoventilation Syndrome

Launched by ASSIUT UNIVERSITY · Jun 2, 2024

Keywords

ClinConnect Summary

Obesity hypoventilation syndrome (OHS) is one of the leading indications of home non-invasive ventilation (NIV) initiation. In patients with OHS, NIV improves daytime vigilance, decreases PaCO2, improves sleep quality, and improves physical activity.

Thus, the primary aim of this study was to evaluate the effects of 6-month noninvasive ventilation with average volume-assured pressure support (AVAPS-AE) ventilation on objective sleep quality and adherence to therapy in stable patients with OHS who failed CPAP titration.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • All Clinically stable OHS patients with
• • Body mass index of 30 kg/m2 ,
• • Daytime hypercapnia (PaCO2 \>45 mm Hg) who had failed to respond to CPAP therapy
• • had no other cause for their chronic respiratory failure and were naive to any PAP therapy.
• Exclusion Criteria:
• • Patients with evidence of acute respiratory failure (patients with worsening symptoms during the last 2 weeks before the screening visit, a breathing frequency of 30 breaths/ minute, or signs of respiratory infections)
• • Patients who had been intubated during the last 3 months
• • Patients who had received any other form of ventilatory support before hospital admission were also excluded from the study

Trial Officials